Asymmetric division of stem cells and its cancer relevance.
Cell Regen
; 13(1): 5, 2024 Feb 27.
Article
in En
| MEDLINE
| ID: mdl-38411768
ABSTRACT
Asymmetric division is a fundamental process for generating cell diversity and maintaining the stem cell population. During asymmetric division, proteins, organelles, and even RNA are distributed unequally between the two daughter cells, determining their distinct cell fates. The mechanisms orchestrating this process are extremely complex. Dysregulation of asymmetric division can potentially trigger cancer progression. Cancer stem cells, in particular, undergo asymmetric division, leading to intra-tumoral heterogeneity, which contributes to treatment refractoriness. In this review, we delve into the cellular and molecular mechanisms that govern asymmetric division and explore its relevance to tumorigenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Cell Regen
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
China