Modulation of adipose tissue metabolism by exosomes in obesity.
Am J Physiol Endocrinol Metab
; 326(5): E709-E722, 2024 May 01.
Article
in En
| MEDLINE
| ID: mdl-38416071
ABSTRACT
Obesity and its related metabolic complications represent a significant global health challenge. Central to this is the dysregulation of glucolipid metabolism, with a predominant focus on glucose metabolic dysfunction in the current research, whereas adipose metabolism impairment garners less attention. Exosomes (EXs), small extracellular vesicles (EVs) secreted by various cells, have emerged as important mediators of intercellular communication and have the potential to be biomarkers, targets, and therapeutic tools for diverse diseases. In particular, EXs have been found to play a role in adipose metabolism by transporting cargoes such as noncoding RNAs (ncRNA), proteins, and other factors. This review article summarizes the current understanding of the role of EXs in mediating adipose metabolism disorders in obesity. It highlights their roles in adipogenesis (encompassing adipogenic differentiation and lipid synthesis), lipid catabolism, lipid transport, and white adipose browning. The insights provided by this review offer new avenues for developing exosome-based therapies to treat obesity and its associated comorbidities.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adipose Tissue
/
Adipogenesis
/
Lipid Metabolism
/
Exosomes
/
Obesity
Limits:
Animals
/
Humans
Language:
En
Journal:
Am J Physiol Endocrinol Metab
/
Am. j. physiol. endocrinol. metab
/
Endocrinology and metabolism (Online)
Journal subject:
ENDOCRINOLOGIA
/
FISIOLOGIA
/
METABOLISMO
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos