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Influence of FOXP3 single-nucleotide polymorphism after allogeneic hematopoietic stem cell transplantation.
Kuroiwa, Kai; Sato, Misuzu; Narita, Hinako; Okamura, Reiko; Uesugi, Yuka; Sasaki, Yohei; Shimada, Shotaro; Watanuki, Megumi; Fujiwara, Shun; Kawaguchi, Yukiko; Arai, Nana; Yanagisawa, Kouji; Iezumi, Keiichi; Hattori, Norimichi.
Affiliation
  • Kuroiwa K; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Sato M; Department of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo, Japan.
  • Narita H; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Okamura R; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Uesugi Y; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Sasaki Y; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Shimada S; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Watanuki M; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Fujiwara S; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Kawaguchi Y; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Arai N; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Yanagisawa K; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
  • Iezumi K; Department of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo, Japan.
  • Hattori N; Division of Hematology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. nhattor@med.showa-u.ac.jp.
Int J Hematol ; 119(5): 583-591, 2024 May.
Article in En | MEDLINE | ID: mdl-38418747
ABSTRACT
The impact of FOXP3 single-nucleotide polymorphisms (SNP) on clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains poorly understood. We investigated the relationship between a FOXP3 SNP (rs3761548) and clinical outcomes in 91 patients with hematological malignancies after allo-HSCT. Multivariate analysis showed that risk of severe chronic graft-versus-host disease (cGVHD) was significantly higher in patients with the FOXP3-3279C/A or FOXP3-3279A/A genotype than those with the FOXP3-3279C/C genotype [hazard ratio (HR), 2.69; 95% confidence interval (CI) 1.14-6.31; p = 0.023]. Therefore, FOXP3 at SNP rs3761548 can be a useful marker for predicting the occurrence of severe cGVHD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transplantation, Homologous / Hematopoietic Stem Cell Transplantation / Hematologic Neoplasms / Polymorphism, Single Nucleotide / Forkhead Transcription Factors / Graft vs Host Disease Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Int J Hematol / Int. j. hematol / International journal of hematology Journal subject: HEMATOLOGIA Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Japón
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transplantation, Homologous / Hematopoietic Stem Cell Transplantation / Hematologic Neoplasms / Polymorphism, Single Nucleotide / Forkhead Transcription Factors / Graft vs Host Disease Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Int J Hematol / Int. j. hematol / International journal of hematology Journal subject: HEMATOLOGIA Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Japón