Your browser doesn't support javascript.
loading
Real-time OCT feedback-controlled RPE photodisruption in ex vivo porcine eyes using 8 microsecond laser pulses.
Burri, Christian; Salzmann, Simon; Wandel, Jasmin; Hoffmann, Leonie; Povazay, Boris; Meier, Christoph; Frenz, Martin.
Affiliation
  • Burri C; optoLab, Institute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Switzerland.
  • Salzmann S; Biomedical Photonics Group, Institute of Applied Physics, University of Bern, Bern, Switzerland.
  • Wandel J; optoLab, Institute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Switzerland.
  • Hoffmann L; Institute for Optimisation and Data Analysis, Bern University of Applied Sciences, Burgdorf, Switzerland.
  • Povazay B; optoLab, Institute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Switzerland.
  • Meier C; optoLab, Institute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Switzerland.
  • Frenz M; optoLab, Institute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Switzerland.
Biomed Opt Express ; 14(12): 6328-6349, 2023 Dec 01.
Article in En | MEDLINE | ID: mdl-38420306
ABSTRACT
Selective retinal pigment epithelium (RPE) photodisruption requires reliable real-time feedback dosimetry (RFD) to prevent unwanted overexposure. In this study, optical coherence tomography (OCT) based RFD was investigated in ex vivo porcine eyes exposed to laser pulses of 8 µs duration (wavelength 532 nm, exposure area 90 × 90 µm2, radiant exposure 247 to 1975 mJ/µm2). For RFD, fringe washouts in time-resolved OCT M-scans (central wavelength 870 nm, scan rate 85 kHz) were compared to an RPE cell viability assay. Statistical analysis revealed a moderate correlation between RPE lesion size and applied treatment energy, suggesting RFD adaptation to inter- and intraindividual RPE pigmentation and ocular transmission.
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Biomed Opt Express Year: 2023 Document type: Article Affiliation country: Suiza
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Biomed Opt Express Year: 2023 Document type: Article Affiliation country: Suiza