Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis.
Protein Cell
; 2024 Mar 02.
Article
in En
| MEDLINE
| ID: mdl-38430542
ABSTRACT
Ferroptosis has been recognized as a unique cell death modality driven by excessive lipid peroxidation and unbalanced cellular metabolism. In this study, we established a protein interaction landscape for ferroptosis pathways through proteomic analyses, and identified choline/ethanolamine phosphotransferase 1 (CEPT1) as a lysophosphatidylcholine acyltransferase 3 (LPCAT3)-interacting protein that regulates LPCAT3 protein stability. In contrast to its known role in promoting phospholipid synthesis, we showed that CEPT1 suppresses ferroptosis potentially by interacting with phospholipases and breaking down certain pro-ferroptotic polyunsaturated fatty acid (PUFA)-containing phospholipids. Together, our study reveals a previously unrecognized role of CEPT1 in suppressing ferroptosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Protein Cell
Journal subject:
BIOQUIMICA
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos