Internal absorbed dose calculation in body organs due to injection of Rhenium-188 labeled to Mu-9 antibody.
Appl Radiat Isot
; 207: 111235, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38430824
ABSTRACT
The use of radiopharmaceuticals has gained a special place in the diagnosis and treatment of cancers and evaluation of the function of different organs of the body. In this study, the absorbed dose distribution of organs after injection of 188Re-Mu-9 has been investigated using MIRD method and MCNP-4C simulation code. The 188Re-Mu-9 labeled was injected the mouse body and the amount of 188Re-labeled accumulation was evaluated after 1, 4 and 2 4 h. Having a map of the distribution of radiopharmaceutical activity in the animal body, it is possible to convert it into a human model to obtain the internal dose received by 188Re-Mu-9 injection using the MIRD calculation method and the MCNP simulation code. According to the results of the study, the animal/human model can be acceptable method for dose estimation of antibody-based radiopharmaceuticals.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhenium
/
Radiopharmaceuticals
Limits:
Animals
/
Humans
Language:
En
Journal:
Appl Radiat Isot
Journal subject:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Year:
2024
Document type:
Article
Affiliation country:
Irán
Country of publication:
Reino Unido