Radiosynovectomy in haemophilic synovitis and arthropathy of the knee: A scoping review.
Haemophilia
; 30(3): 617-627, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38439131
ABSTRACT
INTRODUCTION:
Radiosynovectomy is an established treatment for chronic synovitis in patients with haemophilia. Although its role in rheumatological diseases has diminished, it remains an accepted therapy for haemophilic synovitis.AIM:
The aim of this scoping review was to map and summarise the evidence surrounding radiosynovectomy in haemophilic knees, identify gaps in the literature and inform future research.RESULTS:
Forty-three manuscripts and abstracts were identified for this review. Evidence was limited to observational studies and Yttrium-90 was the most studied licensed radioisotope. Radiosynovectomy was associated with a reduction in bleeding frequency and pain, improvements in range of motion and a reduction in the use of factor replacement.CONCLUSION:
The literature reviewed lacks studies of sufficient methodological quality to permit systematic review and meta-analysis. Systematic review using risk of bias assessment for observational studies should be undertaken to better evaluate the efficacy and safety of radiosynovectomy. A causal relationship between RSV and key clinical outcomes remains undetermined.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synovitis
/
Hemophilia A
/
Knee Joint
Limits:
Humans
Language:
En
Journal:
Haemophilia
Journal subject:
HEMATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Reino Unido