Your browser doesn't support javascript.
loading
Single-pool model urea clearance index is associated with sarcopenia and nutritional status in patients undergoing maintenance hemodialysis: a cross-sectional study.
Li, Yan; Xing, Tingting; Xu, Rong; Liu, Yan; Zhong, Xiaoshi; Liu, Yun; Tan, Rongshao.
Affiliation
  • Li Y; Department of Nephrology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China.
  • Xing T; Department of Nephrology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China.
  • Xu R; Department of Nephrology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China.
  • Liu Y; Department of Nephrology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China.
  • Zhong X; Department of Clinical Nutrition, Institute of Disease-Oriented Nutritional Research, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China.
  • Liu Y; Department of Nephrology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China.
  • Tan R; Department of Nephrology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China.
BMC Nephrol ; 25(1): 80, 2024 Mar 05.
Article in En | MEDLINE | ID: mdl-38443824
ABSTRACT

BACKGROUND:

The single-pool model urea clearance index (single-pool Kt/Vurea; spKt/V) is the most commonly used method for dialysis adequacy assessment. However, only a few studies have examined the relationship between spKt/V values and parameters related to sarcopenia and nutritional status. This study aimed to evaluate whether the spKt/V is an indicator of sarcopenia and nutritional status in patients undergoing maintenance hemodialysis (MHD).

METHODS:

A total of 142 patients were included in this single-center, cross-sectional study. Venous blood samples were collected shortly before the hemodialysis session. The adequacy of dialysis in patients receiving MHD was assessed using spKt/V. Sarcopenia was identified according to the Asian Working Group for Sarcopenia (2019) definition. Receiver operating characteristic curve and area under the curve were used to evaluate the predictive value of spKt/V in sarcopenia. Univariate and multivariate binary logistic regression analyses were used to determine the association between spKt/V and sarcopenia and nutritional status.

RESULTS:

The mean spKt/V level was 1.3 ± 0.2, the prevalence of sarcopenia was 15.5% in patients on MHD. The best cutoff value of spKt/V in sarcopenia was 1.45 for both sexes, 1.33 and 1.45 for men and women, respectively (P < 0.05). The multivariate binary logistic regression shown that the spKt/V was independently positively associated with sarcopenia (OR = 122.88, 95% CI = 0.64-0.87, P = 0.002). Grouping spKt/V by the best cutoff value, when spKt/V ≥ 1.45, the OR of sarcopenia was 11.75 (95% CI = 3.16-43.67, P < 0.001). Subgroup analyses showed that when spKt/V ≥ 1.33 in men and spKt/V ≥ 1.45 in woman, the OR of sarcopenia was 9.73 (95% CI = 2.25-42.11, P = 0.002) and 14.52 (95% CI = 1.06-199.67, P = 0.045), respectively.

CONCLUSIONS:

The present study showed that spKt/V was an important influencing factor of sarcopenia and malnutrition in Asian patients on MHD.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nutritional Status / Sarcopenia Limits: Female / Humans / Male Language: En Journal: BMC Nephrol Journal subject: NEFROLOGIA Year: 2024 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nutritional Status / Sarcopenia Limits: Female / Humans / Male Language: En Journal: BMC Nephrol Journal subject: NEFROLOGIA Year: 2024 Document type: Article Affiliation country: China