Physiological and immunological barriers in the lung.
Semin Immunopathol
; 45(4-6): 533-547, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-38451292
ABSTRACT
The lungs serve as the primary organ for respiration, facilitating the vital exchange of gases with the bloodstream. Given their perpetual exposure to external particulates and pathogens, they possess intricate protective barriers. Cellular adhesion in the lungs is robustly maintained through tight junctions, adherens junctions, and desmosomes. Furthermore, the pulmonary system features a mucociliary clearance mechanism that synthesizes mucus and transports it to the outside. This mucus is enriched with chemical barriers like antimicrobial proteins and immunoglobulin A (IgA). Additionally, a complex immunological network comprising epithelial cells, neural cells, and immune cells plays a pivotal role in pulmonary defense. A comprehensive understanding of these protective systems offers valuable insights into potential pathologies and their therapeutic interventions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lung
Limits:
Animals
/
Humans
Language:
En
Journal:
Semin Immunopathol
/
Semin. immunopathol
/
Seminars in immunopathology
Journal subject:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Japón
Country of publication:
Alemania