Photocatalyzed Direct α-Alkylation of Esters Using Styrenes.
Adv Synth Catal
; 365(14): 2361-2366, 2023 Jul 18.
Article
in En
| MEDLINE
| ID: mdl-38464363
ABSTRACT
A mild photocatalyzed approach to achieve the α-alkylation of esters via formation of an α -radical is disclosed here. Cesium enolates of esters were generated in situ using Cs2CO3 as a base. A subsequent photocatalyzed oxidation at the α-carbon of these enolates produced an α-radical that was added into activated alkenes. This is the first example accessing the α-carbon radical of esters in photoredox catalyed transformations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Adv Synth Catal
Year:
2023
Document type:
Article
Country of publication:
Alemania