In vitro Evaluation of the Antileishmanial and Antischistosomal Activities of p-Coumaric Acid Prenylated Derivatives.
Chem Biodivers
; 21(5): e202400491, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38470945
ABSTRACT
We have evaluated eight p-coumaric acid prenylated derivatives inâ
vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 ((E)-3,4-diprenyl-4-isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC50=45.92â
µM) and S. mansoni (IC50=64.25â
µM). Data indicated that the number of prenyl groups, the presence of hydroxyl at C9, and a single bond between C7 and C8 are important structural features for the antileishmanial activity of p-coumaric acid prenylated derivatives.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schistosoma mansoni
/
Coumaric Acids
/
Parasitic Sensitivity Tests
/
Leishmania
/
Antiprotozoal Agents
Limits:
Animals
Language:
En
Journal:
Chem Biodivers
/
Chem. biodivers. (Online)
/
Chemistry & biodiversity (Online)
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2024
Document type:
Article
Affiliation country:
Brasil
Country of publication:
Suiza