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Defining the Minimal Important Change and Meaningful Change Value of the Disease Activity Index for Psoriatic Arthritis: A Chinese Longitudinal Study.
Liu, Yijie; Tan, Minjia; Hu, Kun; Deng, Sichun; Jian, Lu; Chen, Junchen; Zhang, Mi; Kuang, Yehong.
Affiliation
  • Liu Y; Y. Liu, BS, K. Hu, BS, S. Deng, BS, L. Jian, BS, J. Chen, MD, M. Zhang, MD, Y. Kuang, MD, Department of Dermatology, Xiangya Hospital, Central South University, and National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), and Hunan Engineering Research Center of Skin Health and
  • Tan M; M. Tan, BS, Department of Dermatology, Xiangya Hospital, Central South University, Changsha, and Department of Dermatology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
  • Hu K; Y. Liu, BS, K. Hu, BS, S. Deng, BS, L. Jian, BS, J. Chen, MD, M. Zhang, MD, Y. Kuang, MD, Department of Dermatology, Xiangya Hospital, Central South University, and National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), and Hunan Engineering Research Center of Skin Health and
  • Deng S; Y. Liu, BS, K. Hu, BS, S. Deng, BS, L. Jian, BS, J. Chen, MD, M. Zhang, MD, Y. Kuang, MD, Department of Dermatology, Xiangya Hospital, Central South University, and National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), and Hunan Engineering Research Center of Skin Health and
  • Jian L; Y. Liu, BS, K. Hu, BS, S. Deng, BS, L. Jian, BS, J. Chen, MD, M. Zhang, MD, Y. Kuang, MD, Department of Dermatology, Xiangya Hospital, Central South University, and National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), and Hunan Engineering Research Center of Skin Health and
  • Chen J; Y. Liu, BS, K. Hu, BS, S. Deng, BS, L. Jian, BS, J. Chen, MD, M. Zhang, MD, Y. Kuang, MD, Department of Dermatology, Xiangya Hospital, Central South University, and National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), and Hunan Engineering Research Center of Skin Health and
  • Zhang M; Y. Liu, BS, K. Hu, BS, S. Deng, BS, L. Jian, BS, J. Chen, MD, M. Zhang, MD, Y. Kuang, MD, Department of Dermatology, Xiangya Hospital, Central South University, and National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), and Hunan Engineering Research Center of Skin Health and
  • Kuang Y; Y. Liu, BS, K. Hu, BS, S. Deng, BS, L. Jian, BS, J. Chen, MD, M. Zhang, MD, Y. Kuang, MD, Department of Dermatology, Xiangya Hospital, Central South University, and National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), and Hunan Engineering Research Center of Skin Health and
J Rheumatol ; 51(7): 678-681, 2024 Jul 01.
Article in En | MEDLINE | ID: mdl-38490673
ABSTRACT

OBJECTIVE:

To determine the minimal important change (MIC) and meaningful change value (MCV) of the Disease Activity Index for Psoriatic Arthritis (DAPSA) and the effect size (ES) of DAPSA.

METHODS:

This was a retrospective cohort study, recruiting 106 patients who agreed to participate in the research from the Department of Dermatology, Xiangya Hospital, between November 1, 2019, and April 1, 2023. An anchor-based method using linear regression analyses was used to determine the MICs and MCVs of the DAPSA. The anchor question assessed whether the patient's well-being had changed since their previous visit, employing a 5-point Likert scale that ranged from "much improved" to "much deteriorated."

RESULTS:

The overall MIC value was 8.4 (95% CI 0.01-16.75). The MIC improvement was 9.5 (95% CI 0.89-18.14) and MIC deterioration was 1.1 (95% CI -9.81 to 12.05). The overall MCV was 10.5 (95% CI 4.34-16.72). MCV improvement was 11.4 (95% CI 5.95-16.95) and MCV deterioration was 1.1 (95% CI -9.81 to 12.05). The ES was 0.6.

CONCLUSION:

A change in DAPSA of 8.4 is indicative of an MIC, offering physicians an additional means to contextualize the patient's perception of disease activity during treatment, and a change in DAPSA of 10.5 is likely to be regarded as MCV. These values can enhance the utility of DAPSA in psoriatic arthritis clinical trials.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Severity of Illness Index / Arthritis, Psoriatic Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Rheumatol Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Severity of Illness Index / Arthritis, Psoriatic Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Rheumatol Year: 2024 Document type: Article