Noninvasive biomarkers for lupus nephritis.
Lab Med
; 2024 Mar 17.
Article
in En
| MEDLINE
| ID: mdl-38493322
ABSTRACT
Lupus nephritis (LN) is one of the most severe clinical manifestations of systemic lupus erythematosus (SLE). Notably, the clinical manifestations of LN are not always consistent with the histopathological findings. Therefore, the diagnosis and activity monitoring of this disease are challenging and largely depend on invasive renal biopsy. Renal biopsy has side effects and is associated with the risk of bleeding and infection. There is a growing interest in the development of novel noninvasive biomarkers for LN. In this review, we summarize most of the LN biomarkers discovered so far by correlating current knowledge with future perspectives. These biomarkers fundamentally reflect the biological processes of kidney damage and repair during disease. Furthermore, this review highlights the role of urinary cell phenotype detection in the diagnosis, monitoring, and treatment of LN and summarizes the limitations and countermeasures of this test.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Lab Med
Year:
2024
Document type:
Article
Affiliation country:
China