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Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection.
Dai, Wenkui; Du, Hui; Zhou, Qian; Li, Sumei; Wang, Yinan; Hou, Jun; Guo, Chunlei; Yang, Qing; Li, Changzhong; Xie, Shouxia; Li, Shuai Cheng; Wu, Ruifang.
Affiliation
  • Dai W; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
  • Du H; Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.
  • Zhou Q; Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, China.
  • Li S; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
  • Wang Y; Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.
  • Hou J; Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, China.
  • Guo C; Department of Computer Science, City University of Hong Kong, Hong Kong, China.
  • Yang Q; Department of Pharmacology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.
  • Li C; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
  • Xie S; Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.
  • Li SC; Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, China.
  • Wu R; Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China.
NPJ Biofilms Microbiomes ; 10(1): 26, 2024 Mar 20.
Article in En | MEDLINE | ID: mdl-38509123
ABSTRACT
There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Papillomavirus Infections / Microbiota Limits: Female / Humans Language: En Journal: NPJ Biofilms Microbiomes Year: 2024 Document type: Article Affiliation country: China
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Papillomavirus Infections / Microbiota Limits: Female / Humans Language: En Journal: NPJ Biofilms Microbiomes Year: 2024 Document type: Article Affiliation country: China