A multi-functional nano-platform based on LiGa4.99O8:Cr0.01/IrO2 with near infrared-persistent luminescence, "afterglow" photodynamic and photo-thermal functions.
Dalton Trans
; 53(15): 6601-6608, 2024 Apr 16.
Article
in En
| MEDLINE
| ID: mdl-38512315
ABSTRACT
Multi-functionalised nano-platforms based on persistent-luminescence nanoparticles (PLNPs) have attracted considerable attention for biomedical applications owing to their lack of background noise and suitability for in vivo imaging without the need for in situ excitation. However, nano-platforms based on PLNPs for continuous photodynamic therapy (PDT) are currently lacking. Herein, we report a nano-platform (LiGa4.99O8Cr0.01/IrO2, LGOCr/IrO2) prepared using PLNPs (LiGa4.99O8Cr0.01, LGOCr) covalently bonded with iridium oxide nanoparticles (IrO2 NPs), producing near-infrared (NIR) persistent luminescence, "afterglow" PDT and photo-thermal therapy (PTT) effects. The LGOCr/IrO2 not only exhibits NIR-persistent luminescence at 719 nm and a PTT effect under 808 nm irradiation but also a continuous "afterglow" PDT effect without the need for in situ excitation owing to persistent energy transfer from LGOCr to the IrO2 NPs, in turn generating reactive oxygen species (ROS). This multi-functional nano-platform is expected to further promote the application of PLNPs in tumour treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nanoparticles
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Dalton Trans
Journal subject:
QUIMICA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Reino Unido