Prognosis and prognostic factors of lung cancer complications in patients with rheumatoid arthritis.
Int J Rheum Dis
; 27(3): e15069, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38514918
ABSTRACT
AIM:
To clarify the prognosis and prognostic factors for lung cancer in patients with rheumatoid arthritis (RA).METHODS:
In this retrospective longitudinal study, we investigated the medical records of patients with RA among 1422 patients diagnosed with lung cancer and registered in a hospital-based cancer registry between January 2013 and May 2022. The Kaplan-Meier method and Cox proportional hazards model were used to analyze survival and identify predictive factors.RESULTS:
Of 26 patients with RA complicated with lung cancer (median age, 69 years), the 2-year overall survival rates for stages I-II were 90%-100%, and those for stages III-IV were 20%, respectively. Positivity of anti-citrullinated protein/peptide antibody, smoking history, interstitial lung disease, poorly controlled RA, stage III and IV lung cancer, histological types other than adenocarcinoma and squamous cell carcinoma, and RF ⧠50 IU/mL were associated with increased mortality. After the surgical resection of stage I and II lung cancer, 5 of the 16 patients experienced cancer recurrence after resumption of RA treatment, and the histology of the recurrent cancers was mostly squamous cell carcinoma.CONCLUSIONS:
Early detection of lung cancer is needed, especially in patients with RA who have a history of smoking, seropositivity, or interstitial lung disease. Even after surgical resection, it should be noted that squamous cell carcinoma is prone to recurrence.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Rheumatoid
/
Carcinoma, Squamous Cell
/
Lung Diseases, Interstitial
/
Lung Neoplasms
Limits:
Aged
/
Humans
Language:
En
Journal:
Int J Rheum Dis
Journal subject:
REUMATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Japón