Potential causal association between leisure sedentary behaviors and osteoporosis: A two-sample Mendelian randomization analysis.
Medicine (Baltimore)
; 103(12): e37467, 2024 Mar 22.
Article
in En
| MEDLINE
| ID: mdl-38518020
ABSTRACT
Previous observational studies have observed a correlation between sedentary behavior and osteoporosis. However, conclusions from these studies have been contradictory. To explore the potential causal relationship between sedentary behavior and osteoporosis, we conducted a Mendelian randomization analysis. A two-sample Mendelian randomization was adopted to explore the causal relationship of leisure sedentary behavior with osteoporosis. We employed 5 methods to estimate the causal associations between leisure sedentary behavior and osteoporosis. Univariable Mendelian randomization results provided evidence for the causal relationship of the time spent on computer-use with the bone mineral density estimated by heel quantitative ultrasound (eBMD) (inverse variance weighted [IVW] ß (95% confidence interval [CI])â
-â
0.150 (-0.270 to -0.031), Pâ
=â
.013; weighted median ß (95%CI)â
-â
0.195 (-0.336 to -0.055), Pâ
=â
.006). Similar associations were observed in the driving forearm bone mineral density (FABMD) (IVW ß (95%CI)â
-â
0.933 (-1.860 to -0.007), Pâ
=â
.048) and driving lumbar spine bone mineral density (IVW ß (95%CI)â
-â
0.649 (-1.175 to -0.124), Pâ
=â
.015). However, we did not find a significant causal relationship between the time spent on watching TV and bone mineral density. Research showed that there was a causal relationship between the time spent on computer use and driving time and eBMD, FABMD, and lumbar spine bone mineral density.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoporosis
/
Cogan Syndrome
/
Sedentary Behavior
Limits:
Humans
Language:
En
Journal:
Medicine (Baltimore)
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Estados Unidos