Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models.
Biology (Basel)
; 13(3)2024 Mar 12.
Article
in En
| MEDLINE
| ID: mdl-38534450
ABSTRACT
Redox balance is increasingly identified as a major player in cellular signaling. A fundamentally simple reaction of oxidation and reduction of cysteine residues in cellular proteins is the central concept in this complex regulatory mode of protein function. Oxidation of key cysteine residues occurs at the physiological levels of reactive oxygen species (ROS), but they are reduced by a supply of thiol antioxidant molecules including glutathione, glutaredoxin, and thioredoxin. While these molecules show complex compensatory roles in experimental conditions, transgenic animal models provide a comprehensive picture to pinpoint the role of each antioxidant. In this review, we have specifically focused on the available literature on thioredoxin-1 system transgenic models that include thioredoxin and thioredoxin reductase proteins. As the identification of thioredoxin protein targets is technically challenging, the true contribution of this system in maintaining cellular balance remains unidentified, including the role of this system in the brain.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Biology (Basel)
Year:
2024
Document type:
Article
Affiliation country:
Canadá
Country of publication:
Suiza