Trait-dependent effects of theta burst stimulation after psychosocial stress: a sham-controlled study in healthy individuals.
Clin Neurophysiol
; 162: 235-247, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38556367
ABSTRACT
OBJECTIVE:
Previous studies suggest that theta burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (rTMS), applied to the left dorsolateral prefrontal cortex (DLPFC) might be a promising approach to modulate stress-reactive rumination and the associated psychophysiological stress response. Crucially, individuals showing higher levels of trait rumination might benefit more from prefrontal stimulation.METHODS:
In this sham-controlled study, 127 healthy individuals, with varying ruminative tendencies, received a single-session of intermittent TBS (iTBS), continuous TBS (cTBS) or sham TBS (sTBS) over the left DLPFC before being confronted with a Trier Social Stress Test.RESULTS:
Results showed significant TBS effects on salivary cortisol as a function of trait rumination. cTBS, as compared to sTBS and iTBS, resulted in an attenuated stress-induced cortisol response in high compared to low trait ruminators. Although independent of trait rumination levels, cTBS showed positive effects on stress-related changes in mood and, both cTBS and iTBS (versus sham) presented an enhanced heart rate recovery following the stressor. We found no evidence for (trait rumination-dependent) TBS effects on stress-reactive rumination, negative affect, subjective stress or heart rate variability.CONCLUSIONS:
cTBS shows beneficial effects on certain measures of stress, especially in high trait ruminators.SIGNIFICANCE:
These findings highlight the importance of accounting for individual differences when examining TBS effects.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stress, Psychological
/
Theta Rhythm
/
Hydrocortisone
/
Transcranial Magnetic Stimulation
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Neurophysiol
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2024
Document type:
Article
Country of publication:
Países Bajos