Sacubitril/valsartan alleviates sunitinib-induced cardiac fibrosis and oxidative stress via improving TXNIP/TRX system and downregulation of NF-Ä¸B/Wnt/ß-catenin/SOX9 signaling.

Mohamad, Hoda E; Askar, Mervat E; Shaheen, Mohamed A; Baraka, Nourhan M; Mahmoud, Yasmin K

Mohamad, Hoda E; Askar, Mervat E; Shaheen, Mohamed A; Baraka, Nourhan M; Mahmoud, Yasmin K.

Affiliation

Mohamad HE; Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Askar ME; Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: MAAskar@pharmacy.zu.edu.eg.
Shaheen MA; Department of Histology & Cell Biology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Baraka NM; Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Mahmoud YK; Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.

Int Immunopharmacol ; 132: 111963, 2024 May 10.

Article in En | MEDLINE | ID: mdl-38560962

Subject(s)
Key words

Cardiac fibrosis; SOX9; Sacubitril/valsartan; Sunitinib; TXNIP/TRX; Wnt/ß-catenin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrazoles / Thioredoxins / Biphenyl Compounds / Fibrosis / NF-kappa B / Rats, Wistar / Oxidative Stress / Drug Combinations / Wnt Signaling Pathway / Valsartan Limits: Animals Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2024 Document type: Article Affiliation country: Egipto Country of publication: Países Bajos

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