Quercetin inhibition of porcine intestinal alpha coronavirus in vitro and in vivo.
BMC Vet Res
; 20(1): 134, 2024 Apr 03.
Article
in En
| MEDLINE
| ID: mdl-38570774
ABSTRACT
BACKGROUND:
Porcine acute diarrhea syndrome coronavirus (SADS-CoV) is one of the novel pathogens responsible for piglet diarrhea, contributing to substantial economic losses in the farming sector. The broad host range of SADS-CoV raises concerns regarding its potential for cross-species transmission. Currently, there are no effective means of preventing or treating SADS-CoV infection, underscoring the urgent need for identifying efficient antiviral drugs. This study focuses on evaluating quercetin as an antiviral agent against SADS-CoV.RESULTS:
In vitro experiments showed that quercetin inhibited SADS-CoV proliferation in a concentration-dependent manner, targeting the adsorption and replication stages of the viral life cycle. Furthermore, quercetin disrupts the regulation of the P53 gene by the virus and inhibits host cell cycle progression induced by SADS-CoV infection. In vivo experiments revealed that quercetin effectively alleviated the clinical symptoms and intestinal pathological damage caused by SADS-CoV-infected piglets, leading to reduced expression levels of inflammatory factors such as TLR3, IL-6, IL-8, and TNF-α.CONCLUSIONS:
Therefore, this study provides compelling evidence that quercetin has great potential and promising applications for anti- SADS-CoV action.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Swine Diseases
/
Coronavirus Infections
/
Coronavirus
/
Alphacoronavirus
Limits:
Animals
Language:
En
Journal:
BMC Vet Res
/
BMC vet. res
/
BMC veterinary research
Journal subject:
MEDICINA VETERINARIA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Reino Unido