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The Virtual Child.
Gilbertson, Richard J; Behjati, Sam; Böttcher, Anna-Lisa; Bronner, Marianne E; Burridge, Matthew; Clausing, Henrick; Clifford, Harry; Danaher, Tracey; Donovan, Laura K; Drost, Jarno; Eggermont, Alexander M M; Emerson, Chris; Flores, Mona G; Hamerlik, Petra; Jabado, Nada; Jones, Andrew; Kaessmann, Henrick; Kleinman, Claudia L; Kool, Marcel; Kutscher, Lena M; Lindberg, Gavin; Linnane, Emily; Marioni, John C; Maris, John M; Monje, Michelle; Macaskill, Alexandra; Niederer, Steven; Northcott, Paul A; Peeters, Elizabeth; Plieger-van Solkema, Willemijn; Preußner, Liane; Rios, Anne C; Rippe, Karsten; Sandford, Peter; Sgourakis, Nikolaos G; Shlien, Adam; Smith, Pete; Straathof, Karin; Sullivan, Patrick J; Suvà, Mario L; Taylor, Michael D; Thompson, Emma; Vento-Tormo, Roser; Wainwright, Brandon J; Wechsler-Reya, Robert J; Westermann, Frank; Winslade, Shannon; Al-Lazikani, Bissan; Pfister, Stefan M.
Affiliation
  • Gilbertson RJ; CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
  • Behjati S; Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
  • Böttcher AL; Wellcome Sanger Institute, Hinxton, United Kingdom.
  • Bronner ME; Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
  • Burridge M; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
  • Clausing H; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Clifford H; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Danaher T; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California.
  • Donovan LK; Amazon Web Services, London, United Kingdom.
  • Drost J; SELECT SouthWest, Germany.
  • Eggermont AMM; NVIDIA, Cambridge, United Kingdom.
  • Emerson C; Children's Cancer Foundation, Australia.
  • Flores MG; University College London Great Ormond Street Institute of Child Health, United Kingdom.
  • Hamerlik P; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Jabado N; Oncode Institute, Utrecht, the Netherlands.
  • Jones A; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Kaessmann H; NVIDIA, Cambridge, United Kingdom.
  • Kleinman CL; NVIDIA, Santa Clara, California.
  • Kool M; University of Manchester, Manchester, United Kingdom.
  • Kutscher LM; Department of Paediatrics, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
  • Lindberg G; Amazon Web Services, London, United Kingdom.
  • Linnane E; Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany.
  • Marioni JC; Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada.
  • Maris JM; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
  • Monje M; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Macaskill A; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Niederer S; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Northcott PA; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
  • Peeters E; Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Plieger-van Solkema W; The EVAN Foundation, Maryland.
  • Preußner L; CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
  • Rios AC; Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
  • Rippe K; CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
  • Sandford P; Wellcome Sanger Institute, Hinxton, United Kingdom.
  • Sgourakis NG; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom.
  • Shlien A; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Smith P; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Straathof K; Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.
  • Sullivan PJ; AstraZeneca, Oncology R&D, Cambridge, United Kingdom.
  • Suvà ML; Turing Research and Innovation Cluster in Digital Twins (TRIC: DT), The Alan Turing Institute, London, United Kingdom.
  • Taylor MD; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee.
  • Thompson E; b.r.a.i.n.child, SickKids Hospital, Toronto, Ontario, Canada.
  • Vento-Tormo R; Dutch Childhood Cancer Organization (VKKN), the Netherlands.
  • Wainwright BJ; BioNTech SE, Mainz, Germany.
  • Wechsler-Reya RJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Westermann F; German Cancer Research Center (DKFZ) Heidelberg, Division of Chromatin Networks, Heidelberg, Germany.
  • Winslade S; Amazon Web Services, London, United Kingdom.
  • Al-Lazikani B; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Pfister SM; Department of Pathology and Lab Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Cancer Discov ; 14(4): 663-668, 2024 Apr 04.
Article in En | MEDLINE | ID: mdl-38571421
ABSTRACT

SUMMARY:

We are building the world's first Virtual Child-a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will "develop cancer" that we will subject to unlimited virtual clinical trials that pinpoint, predict, and prioritize potential new treatments, bringing forward the day when no child dies of cancer, giving each one the opportunity to lead a full and healthy life.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplasms Limits: Humans Language: En Journal: Cancer Discov Year: 2024 Document type: Article Affiliation country: Reino Unido
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplasms Limits: Humans Language: En Journal: Cancer Discov Year: 2024 Document type: Article Affiliation country: Reino Unido