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Long-term co-circulation of multiple influenza A viruses in pigs, Guangxi, China.
Huang, Chongqiang; Yu, Liangzheng; Xu, Yi; Huang, Jiamo; Qin, Yibin; Guo, Xuan; Zeng, Yongfang; Qin, Yifeng; Ouyang, Kang; Wei, Zuzhang; Huang, Weijian; García-Sastre, Adolfo; Chen, Ying.
Affiliation
  • Huang C; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.
  • Yu L; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
  • Xu Y; Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, People's Republic of China.
  • Huang J; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.
  • Qin Y; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.
  • Guo X; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
  • Zeng Y; Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, People's Republic of China.
  • Qin Y; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.
  • Ouyang K; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.
  • Wei Z; Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, People's Republic of China.
  • Huang W; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.
  • García-Sastre A; Guangxi Institute of Veterinary Medicine, Nanning, People's Republic of China.
  • Chen Y; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.
Emerg Microbes Infect ; 13(1): 2337673, 2024 Dec.
Article in En | MEDLINE | ID: mdl-38572517
ABSTRACT
Influenza A viruses (IAVs) pose a persistent potential threat to human health because of the spillover from avian and swine infections. Extensive surveillance was performed in 12 cities of Guangxi, China, during 2018 and 2023. A total of 2540 samples (including 2353 nasal swabs and 187 lung tissues) were collected from 18 pig farms with outbreaks of respiratory disease. From these, 192 IAV-positive samples and 19 genomic sequences were obtained. We found that the H1 and H3 swine influenza A viruses (swIAVs) of multiple lineages and genotypes have continued to co-circulate during that time in this region. Genomic analysis revealed the Eurasian avian-like H1N1 swIAVs (G4) still remained predominant in pig populations. Strikingly, the novel multiple H3N2 genotypes were found to have been generated through the repeated introduction of the early H3N2 North American triple reassortant viruses (TR H3N2 lineage) that emerged in USA and Canada in 1998 and 2005, respectively. Notably, when the matrix gene segment derived from the H9N2 avian influenza virus was introduced into endemic swIAVs, this produced a novel quadruple reassortant H1N2 swIAV that could pose a potential risk for zoonotic infection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Swine Diseases / Orthomyxoviridae Infections / Influenza, Human / Influenza A Virus, H1N1 Subtype / Influenza A Virus, H9N2 Subtype Limits: Animals / Humans Country/Region as subject: Asia Language: En Journal: Emerg Microbes Infect Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Swine Diseases / Orthomyxoviridae Infections / Influenza, Human / Influenza A Virus, H1N1 Subtype / Influenza A Virus, H9N2 Subtype Limits: Animals / Humans Country/Region as subject: Asia Language: En Journal: Emerg Microbes Infect Year: 2024 Document type: Article