A formal vinylic substitution reaction for the synthesis of α,ß-unsaturated enol esters and their anticancer potential.
Org Biomol Chem
; 22(16): 3273-3278, 2024 04 24.
Article
in En
| MEDLINE
| ID: mdl-38572769
ABSTRACT
Arylsulfonyl group-bearing α,ß-unsaturated enol esters were readily assembled via the Cs2CO3-mediated union of 2-bromoallyl sulfones and cinnamic acids. The overall transformation is equivalent to an sp2 carbon-oxygen coupling reaction, and therefore constitutes a formal vinylic substitution. Several of the products display promising levels of antiproliferative activities higher than that of the anticancer drug carboplatin. Thiophenol reacted with 2-bromoallyl sulfones under identical conditions to afford α-thiophenyl-α'-tosyl acetone via an apparent aerial oxidation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Proliferation
/
Esters
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2024
Document type:
Article
Affiliation country:
India