Frontal Cortex Lipid Alterations During the Onset of Alzheimer's Disease.
J Alzheimers Dis
; 98(4): 1515-1532, 2024.
Article
in En
| MEDLINE
| ID: mdl-38578893
ABSTRACT
Background:
Although sporadic Alzheimer's disease (AD) is a neurodegenerative disorder of unknown etiology, familial AD is associated with specific gene mutations. A commonality between these forms of AD is that both display multiple pathogenic events including cholinergic and lipid dysregulation.Objective:
We aimed to identify the relevant lipids and the activity of their related receptors in the frontal cortex and correlating them with cognition during the progression of AD.Methods:
MALDI-mass spectrometry imaging (MSI) and functional autoradiography was used to evaluate the distribution of phospholipids/sphingolipids and the activity of cannabinoid 1 (CB1), sphingosine 1-phosphate 1 (S1P1), and muscarinic M2/M4 receptors in the frontal cortex (FC) of people that come to autopsy with premortem clinical diagnosis of AD, mild cognitive impairment (MCI), and no cognitive impairment (NCI).Results:
MALDI-MSI revealed an increase in myelin-related lipids, such as diacylglycerol (DG) 361, DG 385, and phosphatidic acid (PA) 406 in the white matter (WM) in MCI compared to NCI, and a downregulation of WM phosphatidylinositol (PI) 384 and PI 385 levels in AD compared to NCI. Elevated levels of phosphatidylcholine (PC) 321, PC 340, and sphingomyelin 381 were observed in discrete lipid accumulations in the FC supragranular layers during disease progression. Muscarinic M2/M4 receptor activation in layers V-VI decreased in AD compared to MCI. CB1 receptor activity was upregulated in layers V-VI, while S1P1 was downregulated within WM in AD relative to NCI.Conclusions:
FC WM lipidomic alterations are associated with myelin dyshomeostasis in prodromal AD, suggesting WM lipid maintenance as a potential therapeutic target for dementia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alzheimer Disease
/
Cognitive Dysfunction
Limits:
Humans
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Países Bajos