Genetic haute couture to block HIV-1 at front doors.
Cell Stem Cell
; 31(4): 433-434, 2024 Apr 04.
Article
in En
| MEDLINE
| ID: mdl-38579679
ABSTRACT
The chemokine receptors CCR5 and CXCR4 are "front doors" for HIV-1 infection in host cells, and their targeting represents a potential solution for a cure. Dudek et al.1 now propose a new gene editing strategy to simultaneously block CCR5- and CXCR4-mediated HIV-1 entry in autologous hematopoietic stem and progenitor cells (HSPCs).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
HIV-1
Limits:
Humans
Language:
En
Journal:
Cell Stem Cell
/
Cell stem cell (Online)
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos