Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning.
J Zhejiang Univ Sci B
; 25(4): 354-358, 2024 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-38584096
ABSTRACT
Glufosinate-ammonium herbicides are the most widely used broad-spectrum, non-selective herbicides in the world. Glufosinate-ammonium is a structural analogue of glutamate (Glu) which can irreversibly inhibit the activity of glutamine synthetase (GS) and Glu decarboxylase in plants, thereby blocking the synthesis of glutamine (Gln) from Glu and ammonia (Hoerlein, 1994). This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia. In humans, the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity (Watanabe and Sano, 1998). Currently, there are no antidotes for glufosinate-ammonium herbicide poisoning, and thus supportive care is the key treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ammonia
/
Herbicides
Limits:
Humans
Language:
En
Journal:
J Zhejiang Univ Sci B
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
China