Salpingectomy for ectopic pregnancy reduces ovarian cancer risk-a nationwide study.
JNCI Cancer Spectr
; 8(3)2024 Apr 30.
Article
in En
| MEDLINE
| ID: mdl-38588567
ABSTRACT
Recent studies propose fallopian tubes as the tissue origin for many ovarian epithelial cancers. To further support this paradigm, we assessed whether salpingectomy for treating ectopic pregnancy had a protective effect using the Taiwan Longitudinal National Health Research Database. We identified 316â882 women with surgical treatment for ectopic pregnancy and 3â168â820 age- and index-date-matched controls from 2000 to 2016. In a nested cohort, 91.5% of cases underwent unilateral salpingectomy, suggesting that most surgically managed patients have salpingectomy. Over a follow-up period of 17 years, the ovarian carcinoma incidence was 0.0069 (95% confidence interval [CI] = 0.0060 to 0.0079) and 0.0089 (95% CI = 0.0086 to 0.0092) in the ectopic pregnancy and the control groups, respectively (P < .001). After adjusting the events to per 100 person-years, the hazard ratio (HR) in the ectopic pregnancy group was 0.70 (95% CI = 0.61 to 0.80). The risk reduction occurred only in epithelial ovarian cancer (HR = 0.73, 95% CI = 0.63 to 0.86) and not in non-epithelial subtypes. These findings show a decrease in ovarian carcinoma incidence after salpingectomy for treating ectopic pregnancy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Pregnancy, Ectopic
/
Salpingectomy
/
Carcinoma, Ovarian Epithelial
Limits:
Adult
/
Female
/
Humans
/
Middle aged
/
Pregnancy
Country/Region as subject:
Asia
Language:
En
Journal:
JNCI Cancer Spectr
Year:
2024
Document type:
Article
Affiliation country:
Taiwán