Deciphering mitochondrial dysfunction: Pathophysiological mechanisms in vascular cognitive impairment.
Biomed Pharmacother
; 174: 116428, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38599056
ABSTRACT
Vascular cognitive impairment (VCI) encompasses a range of cognitive deficits arising from vascular pathology. The pathophysiological mechanisms underlying VCI remain incompletely understood; however, chronic cerebral hypoperfusion (CCH) is widely acknowledged as a principal pathological contributor. Mitochondria, crucial for cellular energy production and intracellular signaling, can lead to numerous neurological impairments when dysfunctional. Recent evidence indicates that mitochondrial dysfunction-marked by oxidative stress, disturbed calcium homeostasis, compromised mitophagy, and anomalies in mitochondrial dynamics-plays a pivotal role in VCI pathogenesis. This review offers a detailed examination of the latest insights into mitochondrial dysfunction within the VCI context, focusing on both the origins and consequences of compromised mitochondrial health. It aims to lay a robust scientific groundwork for guiding the development and refinement of mitochondrial-targeted interventions for VCI.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxidative Stress
/
Cognitive Dysfunction
/
Mitochondria
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomed Pharmacother
Year:
2024
Document type:
Article
Affiliation country:
China