PsiOvi Staging Model for Schizophrenia (PsiOvi SMS): A New Internet Tool for Staging Patients with Schizophrenia.
Eur Psychiatry
; 67(1): e36, 2024 Apr 11.
Article
in En
| MEDLINE
| ID: mdl-38599765
ABSTRACT
BACKGROUND:
One of the challenges of psychiatry is the staging of patients, especially those with severe mental disorders. Therefore, we aim to develop an empirical staging model for schizophrenia.METHODS:
Data were obtained from 212 stable outpatients with schizophrenia demographic, clinical, psychometric (PANSS, CAINS, CDSS, OSQ, CGI-S, PSP, MATRICS), inflammatory peripheral blood markers (C-reactive protein, interleukins-1RA and 6, and platelet/lymphocyte [PLR], neutrophil/lymphocyte [NLR], and monocyte/lymphocyte [MLR] ratios). We used machine learning techniques to develop the model (genetic algorithms, support vector machines) and applied a fitness function to measure the model's accuracy (% agreement between patient classification of our model and the CGI-S).RESULTS:
Our model includes 12 variables from 5 dimensions 1) psychopathology positive, negative, depressive, general psychopathology symptoms; 2) clinical features number of hospitalizations; 3) cognition processing speed, visual learning, social cognition; 4) biomarkers PLR, NLR, MLR; and 5) functioning PSP total score. Accuracy was 62% (SD = 5.3), and sensitivity values were appropriate for mild, moderate, and marked severity (from 0.62106 to 0.6728).DISCUSSION:
We present a multidimensional, accessible, and easy-to-apply model that goes beyond simply categorizing patients according to CGI-S score. It provides clinicians with a multifaceted patient profile that facilitates the design of personalized intervention plans.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur Psychiatry
/
Eur. psychiatry
/
European psychiatry
Journal subject:
PSIQUIATRIA
Year:
2024
Document type:
Article
Affiliation country:
España
Country of publication:
Reino Unido