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Adamantylglycine as a high-affinity peptide label for membrane transport monitoring and regulation.
Pramod, Malavika; Alnajjar, Mohammad A; Schöpper, Sandra N; Schwarzlose, Thomas; Nau, Werner M; Hennig, Andreas.
Affiliation
  • Pramod M; Center for Cellular Nanoanalytics (CellNanOs) and Department of Biology and Chemistry, Universität Osnabrück, Barbarastraße 7, Osnabrück 49069, Germany. andreas.hennig@uni-osnabrueck.de.
  • Alnajjar MA; Center for Cellular Nanoanalytics (CellNanOs) and Department of Biology and Chemistry, Universität Osnabrück, Barbarastraße 7, Osnabrück 49069, Germany. andreas.hennig@uni-osnabrueck.de.
  • Schöpper SN; Center for Cellular Nanoanalytics (CellNanOs) and Department of Biology and Chemistry, Universität Osnabrück, Barbarastraße 7, Osnabrück 49069, Germany. andreas.hennig@uni-osnabrueck.de.
  • Schwarzlose T; School of Science, Constructor University, Campus Ring 1, Bremen 28759, Germany. wnau@constructor.university.
  • Nau WM; School of Science, Constructor University, Campus Ring 1, Bremen 28759, Germany. wnau@constructor.university.
  • Hennig A; Center for Cellular Nanoanalytics (CellNanOs) and Department of Biology and Chemistry, Universität Osnabrück, Barbarastraße 7, Osnabrück 49069, Germany. andreas.hennig@uni-osnabrueck.de.
Chem Commun (Camb) ; 60(36): 4810-4813, 2024 Apr 30.
Article in En | MEDLINE | ID: mdl-38602391
ABSTRACT
The non-canonical amino acid adamantylglycine (Ada) is introduced into peptides to allow high-affinity binding to cucurbit[7]uril (CB7). Introduction of Ada into a cell-penetrating peptide (CPP) sequence had minimal influence on the membrane transport, yet enabled up- and down-regulation of the membrane transport activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Imidazolidines / Macrocyclic Compounds / Cell-Penetrating Peptides / Glycine / Heterocyclic Compounds, 2-Ring Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Alemania Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Imidazolidines / Macrocyclic Compounds / Cell-Penetrating Peptides / Glycine / Heterocyclic Compounds, 2-Ring Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Alemania Country of publication: Reino Unido