Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications.
Arch Toxicol
; 98(7): 2007-2018, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38602537
ABSTRACT
Gastrointestinal cancer is a significant global health burden, necessitating the development of novel therapeutic strategies. Emerging evidence has highlighted the potential of targeting ferritinophagy as a promising approach for the treatment of gastrointestinal cancer. Ferritinophagy is a form of selective autophagy that is mediated by the nuclear receptor coactivator 4 (NCOA4). This process plays a crucial role in regulating cellular iron homeostasis and has been implicated in various pathological conditions, including cancer. This review discusses the molecular mechanisms underlying ferritinophagy and its relevance to gastrointestinal cancer. Furthermore, we highlight the potential therapeutic implications of targeting ferritinophagy in gastrointestinal cancer. Several approaches have been proposed to modulate ferritinophagy, including small molecule inhibitors and immunotherapeutic strategies. We discuss the advantages and challenges associated with these therapeutic interventions and provide insights into their potential clinical applications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Nuclear Receptor Coactivators
/
Ferritins
/
Gastrointestinal Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Arch Toxicol
/
Arch. toxicol
/
Archives of toxicology
Year:
2024
Document type:
Article
Country of publication:
Alemania