Costs associated with adverse events during treatment episodes for adult attention-deficit/hyperactivity disorder.
J Med Econ
; 27(1): 653-662, 2024.
Article
in En
| MEDLINE
| ID: mdl-38602691
ABSTRACT
OBJECTIVE:
Attention-deficit/hyperactivity disorder (ADHD) medication is frequently associated with adverse events (AEs), but limited real-world data exist regarding their costs from a payer's perspective. Therefore, this study evaluated the healthcare costs associated with common AEs among adult patients treated for ADHD in the US.METHODS:
Eligible adults treated for ADHD were identified from a large US claims database (1 October 2015-30 September 2021). A retrospective cohort study design was used to assess excess healthcare costs and costs directly related to AE-specific claims per-patient-per-month (PPPM) associated with 10 selected AEs during ADHD treatment. To account for all costs associated with the AE, treatment episodes with a given AE were compared to similar treatment episodes without this AE. Entropy balancing was used to create cohorts with similar characteristics. Studied AEs were selected based on their prevalence in clinical trials for common ADHD medications and were identified from ICD-10-CM diagnosis codes recorded in claims.RESULTS:
Among the 461,464 patients included (mean age 34.2 years; 45.5% males), 49.4% had ≥1 AE during their treatment episode. Treatment episodes with AEs were associated with statistically significant AE-specific medical costs (erectile dysfunction $57; fatigue $82; dry mouth $90; diarrhea $162; insomnia $147; anxiety $281; nausea $299; constipation $356; urinary hesitation $491; feeling jittery $723) and excess healthcare costs PPPM (erectile dysfunction $120, fatigue $248, insomnia $265, anxiety $380, diarrhea $441, dry mouth $485, nausea $709, constipation $802, urinary hesitation $1,105, feeling jittery $1,160; p < .05).LIMITATIONS:
AEs were identified based on recorded diagnosis on medical claims and likely represent more severe AEs. Therefore, costs may not be representative of milder AEs.CONCLUSIONS:
This study found that AEs occurring during ADHD treatment episodes are associated with significant healthcare costs. This highlights the potential of treatments with favorable safety profiles to alleviate the burden experienced by patients and the healthcare system.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Attention Deficit Disorder with Hyperactivity
/
Insurance Claim Review
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
J Med Econ
Journal subject:
SERVICOS DE SAUDE
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Reino Unido