Five undescribed cyclopeptides from Cordyceps militaris.
Phytochemistry
; 222: 114074, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38604324
ABSTRACT
Ustiloxins I-M (1-5), five undescribed cyclopeptides bearing a 15-membered macrocyclic skeleton, were isolated from Cordyceps militaris. The structures of 1 and 5 were identified by spectroscopic and crystallographic methods, whereas the structures of 2-4 were assigned by spectroscopic and computational approaches. Biological evaluation of all the compounds toward human triple-negative breast cancer cells revealed that compounds 4 and 5 are toxic with IC50 values of 64.29 µM and 28.89 µM, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides, Cyclic
/
Cordyceps
Limits:
Humans
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article
Country of publication:
Reino Unido