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Airway remodelling in asthma and the epithelium: on the edge of a new era.
Varricchi, Gilda; Brightling, Christopher E; Grainge, Christopher; Lambrecht, Bart N; Chanez, Pascal.
Affiliation
  • Varricchi G; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), School of Medicine, University of Naples Federico II, WAO Center of Excellence, Naples, Italy.
  • Brightling CE; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, Naples, Italy.
  • Grainge C; G. Varricchi and C.E. Brightling contributed equally.
  • Lambrecht BN; Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Chanez P; G. Varricchi and C.E. Brightling contributed equally.
Eur Respir J ; 63(4)2024 Apr.
Article in En | MEDLINE | ID: mdl-38609094
ABSTRACT
Asthma is a chronic, heterogeneous disease of the airways, often characterised by structural changes known collectively as airway remodelling. In response to environmental insults, including pathogens, allergens and pollutants, the epithelium can initiate remodelling via an inflammatory cascade involving a variety of mediators that have downstream effects on both structural and immune cells. These mediators include the epithelial cytokines thymic stromal lymphopoietin, interleukin (IL)-33 and IL-25, which facilitate airway remodelling through cross-talk between epithelial cells and fibroblasts, and between mast cells and airway smooth muscle cells, as well as through signalling with immune cells such as macrophages. The epithelium can also initiate airway remodelling independently of inflammation in response to the mechanical stress present during bronchoconstriction. Furthermore, genetic and epigenetic alterations to epithelial components are believed to influence remodelling. Here, we review recent advances in our understanding of the roles of the epithelium and epithelial cytokines in driving airway remodelling, facilitated by developments in genetic sequencing and imaging techniques. We also explore how new and existing therapeutics that target the epithelium and epithelial cytokines could modify airway remodelling.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Airway Remodeling Limits: Humans Language: En Journal: Eur Respir J Year: 2024 Document type: Article Affiliation country: Italia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Airway Remodeling Limits: Humans Language: En Journal: Eur Respir J Year: 2024 Document type: Article Affiliation country: Italia