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The mechanism of USP43 in the development of tumor: a literature review.
Zhao, Ziqi; Liu, Meichen; Lin, Zhikun; Zhu, Mengru; Lv, Linlin; Zhu, Xinqing; Fan, Rui; Al-Danakh, Abdullah; He, Hui; Tan, Guang.
Affiliation
  • Zhao Z; Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
  • Liu M; Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
  • Lin Z; Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
  • Zhu M; Liaoning Key Laboratory of Molecular Targeted Drugs in Hepatobiliary and Pancreatic Cancer, Dalian 116000, China.
  • Lv L; Department of Plastic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
  • Zhu X; Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
  • Fan R; Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
  • Al-Danakh A; Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, National, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
  • He H; Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
  • Tan G; Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China.
Aging (Albany NY) ; 16(7): 6613-6626, 2024 04 08.
Article in En | MEDLINE | ID: mdl-38613804
ABSTRACT
Ubiquitination of the proteins is crucial for governing protein degradation and regulating fundamental cellular processes. Deubiquitinases (DUBs) have emerged as significant regulators of multiple pathways associated with cancer and other diseases, owing to their capacity to remove ubiquitin from target substrates and modulate signaling. Consequently, they represent potential therapeutic targets for cancer and other life-threatening conditions. USP43 belongs to the DUBs family involved in cancer development and progression. This review aims to provide a comprehensive overview of the existing scientific evidence implicating USP43 in cancer development. Additionally, it will investigate potential small-molecule inhibitors that target DUBs that may have the capability to function as anti-cancer medicines.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplasms Limits: Animals / Humans Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2024 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplasms Limits: Animals / Humans Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2024 Document type: Article Affiliation country: China