Diet and Cancer Metabolism.
Cold Spring Harb Perspect Med
; 2024 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-38621831
ABSTRACT
Diet and exercise are modifiable lifestyle factors known to have a major influence on metabolism. Clinical practice addresses diseases of altered metabolism such as diabetes or hypertension by altering these factors. Despite enormous public interest, there are limited defined diet and exercise regimens for cancer patients. Nevertheless, the molecular basis of cancer has converged over the past 15 years on an essential role for altered metabolism in cancer. However, our understanding of the molecular mechanisms that underlie the impact of diet and exercise on cancer metabolism is in its very early stages. In this work, we propose conceptual frameworks for understanding the consequences of diet and exercise on cancer cell metabolism and tumor biology and also highlight recent developments. By advancing our mechanistic understanding, we also discuss actionable ways that such interventions could eventually reach the mainstay of both medical oncology and cancer control and prevention.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Cold Spring Harb Perspect Med
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos