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Adolescents and young adults (AYA) with cancer: the clinical course of COVID-19 infections.
Wolfson, Julie A; Davis, Elizabeth S; Saha, Aniket; Martinez, Isaac; McCall, David; Kothari, Prachi; Brackett, Julienne; Dickens, David S; Kahn, Alissa R; Schwalm, Carla; Sharma, Archana; Richman, Joshua; Cuglievan, Branko; Bhatia, Smita; Dai, Chen; Levine, Jennifer M; Johnston, Emily E.
Affiliation
  • Wolfson JA; Pediatric Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Davis ES; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Saha A; Department of Surgery, Boston University/Boston Medical Center, Boston, MA, USA.
  • Martinez I; Prisma Health Upstate/BI-LO Charities Children's Cancer Center/Greenville Health System, Greenville, SC, USA.
  • McCall D; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Kothari P; Department of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA.
  • Brackett J; Pediatric Hematology-Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Dickens DS; Pediatric Hematology-Oncology, Department of Pediatrics, Texas Children's Hospital, Houston, TX, USA.
  • Kahn AR; Pediatric Hematology-Oncology, Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
  • Schwalm C; Pediatric Hematology-Oncology, Department of Pediatrics, Saint Joseph's University Medical Center, Paterson, NJ, USA.
  • Sharma A; Pediatric Hematology-Oncology, Department of Pediatrics, Bronson Methodist Hospital, Kalamazoo, MI, USA.
  • Richman J; Pediatric Hematology-Oncology, Department of Pediatrics, Rutgers Cancer Institute, New Brunswick, NJ, USA.
  • Cuglievan B; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Bhatia S; Department of Pediatrics, MD Anderson Cancer Center, Houston, TX, USA.
  • Levine JM; Pediatric Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Johnston EE; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
J Natl Cancer Inst ; 2024 Apr 16.
Article in En | MEDLINE | ID: mdl-38627241
ABSTRACT
Adolescents and Young Adults (AYAs 15-39 y) with cancer face unique vulnerabilities, yet remain under-represented on clinical trials, including adult registries of COVID-19 in cancer (AYAs 8-12%). Thus, we leveraged the Pediatric Oncology COVID-19 Case Report (POCC) to examine the clinical course of COVID-19 among AYAs with cancer. POCC collects de-identified clinical and sociodemographic data regarding 0-39yo with cancer (AYAs = 37%) and COVID-19 from >100 institutions. Between 04/01/2020-11/28/2023, 191 older AYAs [22-39y] and 640 younger AYAs [15-21y] were captured. Older AYAs were less often hospitalized (p < .001), admitted to the intensive care unit (ICU, p = .02), and/or required respiratory support (p = .057). In multivariable analyses, older AYAs faced 80% lower odds of ICU admission but 2.3-times greater odds of changes to cancer-directed therapy. Unvaccinated patients had 5.4-times higher odds of ICU admission. Among AYAs with cancer, the COVID-19 course varies by age. These findings can inform pediatric/adult oncology teams surrounding COVID-19 management and prevention.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Natl Cancer Inst Year: 2024 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Natl Cancer Inst Year: 2024 Document type: Article Affiliation country: Estados Unidos