The Role of Endoplasmic Reticulum Stress in Metabolic Diseases.
Metab Syndr Relat Disord
; 22(7): 487-493, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38666441
ABSTRACT
The endoplasmic reticulum (ER), the center of protein folding, also controls the cell's life-and-death signaling mechanisms. ER stress caused by unfolded or misfolded proteins leads to the activation of the unfolded protein response (UPR) in the cell. The UPR utilizes three main signaling pathways to restore disrupted ER homeostasis. These signaling pathways are protein kinase R-like endoplasmic reticulum kinase, inositol-requiring enzyme 1, and activating transcription factor 6. Studies have reported that ER stress (ERS) plays a role in the pathogenesis of metabolic disorders such as diabetes, obesity, atherosclerosis, and nonalcoholic liver disease. This review will briefly discuss the ERS response in these metabolic diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Unfolded Protein Response
/
Endoplasmic Reticulum Stress
/
Metabolic Diseases
Limits:
Animals
/
Humans
Language:
En
Journal:
Metab Syndr Relat Disord
Journal subject:
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country:
Turquía
Country of publication:
Estados Unidos