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Evolution, control and success of combination therapy with Ampicilin-sulbactam/Ceftazidime-Avibactam during a Carbapenem-Resistant Acinetobacter baumannii outbreak in burn Intensive Care Unit.
Dudoignon, Emmanuel; Caméléna, Francois; Lafaurie, Matthieu; Deniau, Benjamin; Chaussard, Maité; Coutrot, Maxime; Guillemet, Lucie; Cupaciu, Alexandru; Pharaboz, Alexandre; Boutin, Louis; Benyamina, Mourad; Chaouat, Marc; Mimoun, Maurice; Merimèche, Manel; Mebazaa, Alexandre; Plaud, Benoit; Berçot, Béatrice; Dépret, François; Mellon, Guillaume.
Affiliation
  • Dudoignon E; Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis- Lariboisière, 1, avenue Claude Vellefaux, Paris, 75010, France. emmanuel.dudoignon@aphp.fr.
  • Caméléna F; University of Paris Cité, Paris, France. emmanuel.dudoignon@aphp.fr.
  • Lafaurie M; Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM UMR-S 942 Mascot, Lariboisière Hospital, Paris, France. emmanuel.dudoignon@aphp.fr.
  • Deniau B; INI-CRCT Network, Nancy, France. emmanuel.dudoignon@aphp.fr.
  • Chaussard M; FHU PROMICE, Paris, France. emmanuel.dudoignon@aphp.fr.
  • Coutrot M; University of Paris Cité, Paris, France.
  • Guillemet L; Department of Bacteriology, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Paris, France.
  • Cupaciu A; INSERM 1137, IAME, Paris, France.
  • Pharaboz A; Infectious Diseases Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Louis Hospital, Paris, France.
  • Boutin L; Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis- Lariboisière, 1, avenue Claude Vellefaux, Paris, 75010, France.
  • Benyamina M; University of Paris Cité, Paris, France.
  • Chaouat M; Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM UMR-S 942 Mascot, Lariboisière Hospital, Paris, France.
  • Mimoun M; INI-CRCT Network, Nancy, France.
  • Merimèche M; FHU PROMICE, Paris, France.
  • Mebazaa A; Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis- Lariboisière, 1, avenue Claude Vellefaux, Paris, 75010, France.
  • Plaud B; Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis- Lariboisière, 1, avenue Claude Vellefaux, Paris, 75010, France.
  • Berçot B; Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis- Lariboisière, 1, avenue Claude Vellefaux, Paris, 75010, France.
  • Dépret F; Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis- Lariboisière, 1, avenue Claude Vellefaux, Paris, 75010, France.
  • Mellon G; Department of Anesthesiology and Critical Care and Burn Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis- Lariboisière, 1, avenue Claude Vellefaux, Paris, 75010, France.
Eur J Clin Microbiol Infect Dis ; 43(7): 1453-1459, 2024 Jul.
Article in En | MEDLINE | ID: mdl-38676856
ABSTRACT
We present our findings on interpatient transmission, epidemic control measures, and the outcomes of a series of ten critically ill burn patients who were either colonized or infected with carbapenem-resistant Acinetobacter baumannii (CRAB). None of the five infected patients achieved clinical cure, and all experienced relapses. Microbiological failure was observed in 40% of the infected patients. The isolated CRAB strains were found to carry blaOXA-23 and armA resistance genes. Despite the lack of clinical cure, all five infected patients survived and were discharged from the Burn Intensive Care Unit.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acinetobacter Infections / Sulbactam / Carbapenems / Ceftazidime / Disease Outbreaks / Acinetobacter baumannii / Drug Combinations / Azabicyclo Compounds / Intensive Care Units / Anti-Bacterial Agents Language: En Journal: Eur J Clin Microbiol Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2024 Document type: Article Affiliation country: Francia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acinetobacter Infections / Sulbactam / Carbapenems / Ceftazidime / Disease Outbreaks / Acinetobacter baumannii / Drug Combinations / Azabicyclo Compounds / Intensive Care Units / Anti-Bacterial Agents Language: En Journal: Eur J Clin Microbiol Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2024 Document type: Article Affiliation country: Francia