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Quaternary ammonium carboxymethyl chitosan composite hydrogel with efficient antibacterial and antioxidant properties for promoting wound healing.
Ma, Yahao; Zhou, Xujie; Mo, Zhendong; Zhou, Qing; Hui, Bingyu; Cai, Zhuangzhuang; Wang, Xiaoying; Li, Hang; Tang, Shunqing.
Affiliation
  • Ma Y; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  • Zhou X; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  • Mo Z; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  • Zhou Q; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  • Hui B; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  • Cai Z; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  • Wang X; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address: wangxi@jnu.edu.cn.
  • Li H; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address: hangli@jnu.edu.cn.
  • Tang S; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address: tshunqt@jnu.edu.cn.
Int J Biol Macromol ; 268(Pt 2): 131871, 2024 May.
Article in En | MEDLINE | ID: mdl-38677691
ABSTRACT
Multifunctional hydrogels have been developed to meet the various requirements of wound healing. Herein, an innovative hydrogel (QCMC-HA-PEG) was formed through the Schiff base reaction, composed of quaternary ammonium-modified carboxymethyl chitosan (QCMC), hyaluronic acid (HA), and 8-arms Polyethylene Glycol aldehyde (8-ARM-PEG-CHO). The resulting hydrogels exhibited good mechanical and adhesive properties with improved antibacterial efficacy against both Gram-positive and Gram-negative bacteria compared to CMC hydrogels. QCMC-HA-PEG hydrogels demonstrated remarkable adhesive ability in lap-shear test. Furthermore, the incorporation of MnO2 nanosheets into the hydrogel significantly enhanced its reactive oxygen species (ROS) scavenging and oxygen generation capabilities. Finally, experimental results from a full-thickness skin wound model revealed that the QCMC-HA-PEG@MnO2 hydrogel promoted skin epithelization, collagen deposition, and inflammatory regulation significantly accelerated the wound healing process. Therefore, QCMC-HA-PEG@MnO2 hydrogel could be a promising wound dressing to promote wound healing.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wound Healing / Hydrogels / Chitosan / Quaternary Ammonium Compounds / Anti-Bacterial Agents / Antioxidants Limits: Animals Language: En Journal: Int J Biol Macromol Year: 2024 Document type: Article Affiliation country: China Country of publication: Países Bajos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wound Healing / Hydrogels / Chitosan / Quaternary Ammonium Compounds / Anti-Bacterial Agents / Antioxidants Limits: Animals Language: En Journal: Int J Biol Macromol Year: 2024 Document type: Article Affiliation country: China Country of publication: Países Bajos