Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus.
Bull Math Biol
; 86(6): 66, 2024 Apr 28.
Article
in En
| MEDLINE
| ID: mdl-38678489
ABSTRACT
The development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil's nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the development of autoimmunogenicity in SLE. The aim of this work is to study how NETosis contributes to the establishment of persistent autoantigen production by analysing the steady states and the asymptotic dynamics of the model by numerical experiment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apoptosis
/
Models, Immunological
/
Mathematical Concepts
/
Extracellular Traps
/
Lupus Erythematosus, Systemic
/
Neutrophils
Limits:
Humans
Language:
En
Journal:
Bull Math Biol
Year:
2024
Document type:
Article
Affiliation country:
Bulgaria