[Frequency and characteristics of Y chromosome microdeletions and karyotypic abnormalities among 4 278 infertile male patients from southwest China].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 41(5): 513-518, 2024 May 10.
Article
in Zh
| MEDLINE
| ID: mdl-38684293
ABSTRACT
OBJECTIVE:
To determine the frequency and characteristics of AZF microdeletions of Y chromosome and karyotypic abnormalities among infertile male patients from southwest China.METHODS:
4 278 infertile male patients treated at West China Second University Hospital of Sichuan University from September 2018 to July 2023 were selected as the study subjects. Results of Y chromosome microdeletion detection and G-banded karyotyping analysis were retrospectively reviewed.RESULTS:
Clinical data of the patients were collected, which have included 2 048 patients with azoospermia, 1 536 patients with oligozoospermia, 310 patients with mild to moderate oligozoospermia, and 384 patients with infertility but normal sperm concentration. An abnormal karyotype was found in 213 (8.80%) of 2 421 patients who had undergone karyotyping analysis. The frequency of Y chromosome microdeletions was 9.86% (422/4 278), which had occurred in 10.4%, 13.28%, 0.97% and 0.52% of the cases with azoospermia, severe oligozoospermia, mild to moderate oligozoospermia, and infertility with normal sperm concentration, respectively.CONCLUSION:
Y chromosome microdeletion detection and karyotyping analysis are crucial for assessing the cause of male infertility. Early diagnosis can facilitate the selection of reproductive methods.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligospermia
/
Sex Chromosome Aberrations
/
Chromosome Deletion
/
Chromosomes, Human, Y
/
Azoospermia
/
Sex Chromosome Disorders of Sex Development
/
Infertility, Male
/
Karyotyping
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Journal subject:
GENETICA MEDICA
Year:
2024
Document type:
Article
Affiliation country:
China