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VPg-based bidirectional synthetic mRNA circuits enable orthogonal protein regulation for high-resolution cell separation.
Liang, Zhenghua; Hu, Yaxin; Li, Cheuk Yin; Yau, Wai Laam; Tan, Kaixin; Kuang, Yi.
Affiliation
  • Liang Z; Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Room 5578, Academic Bldg, Clear Water Bay, Kowloon, Hong Kong. kekuang@ust.hk.
  • Hu Y; Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Room 5578, Academic Bldg, Clear Water Bay, Kowloon, Hong Kong. kekuang@ust.hk.
  • Li CY; Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Room 5578, Academic Bldg, Clear Water Bay, Kowloon, Hong Kong. kekuang@ust.hk.
  • Yau WL; Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Room 5578, Academic Bldg, Clear Water Bay, Kowloon, Hong Kong. kekuang@ust.hk.
  • Tan K; Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Room 5578, Academic Bldg, Clear Water Bay, Kowloon, Hong Kong. kekuang@ust.hk.
  • Kuang Y; Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Room 5578, Academic Bldg, Clear Water Bay, Kowloon, Hong Kong. kekuang@ust.hk.
Chem Commun (Camb) ; 60(41): 5427-5430, 2024 May 16.
Article in En | MEDLINE | ID: mdl-38685869
ABSTRACT
Synthetic mRNA circuits commonly sense input to produce binary output signals for cell separation. Based on virus-origin cap-independent translation initiation machinery and RBP-aptamer interaction, we designed smart synthetic mRNA-based circuits that sense single input molecules to bidirectionally tune output signals in an orthogonal manner, enabling high-resolution separation of cell populations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Cell Separation Limits: Humans Language: En Journal: Chem Commun (Camb) / Chem. commun. (Lond., 1996, Online) / Chemical communications (London. 1996. Online) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Hong Kong Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Cell Separation Limits: Humans Language: En Journal: Chem Commun (Camb) / Chem. commun. (Lond., 1996, Online) / Chemical communications (London. 1996. Online) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Hong Kong Country of publication: Reino Unido