Analgesia to acidosis: metabolic acidosis due to chronic acetaminophen (paracetamol) use.
BMJ Case Rep
; 17(4)2024 Apr 30.
Article
in En
| MEDLINE
| ID: mdl-38688576
ABSTRACT
This case describes a rare occurrence of high anion gap metabolic acidosis due to chronic acetaminophen (paracetamol) usage, which can be confirmed by measuring 5-oxoproline (pyroglutamate), an organic acid metabolite. As acetaminophen is an extremely common drug prescribed in both inpatient and outpatient settings, a high degree of clinical suspicion is required to isolate it as the aetiology for metabolic acidosis. Management includes discontinuation of acetaminophen use and at times the supplementation of oral bicarbonate. Metabolic acidosis due to a high anion gap is commonly described by the mnemonic 'MUDPILES' in daily practice. A newer mnemonic, 'GOLD MARK' is proposed to be a more inclusive tool to assist in determining the cause of high anion gap metabolic acidosis, especially with such cases being reported.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acidosis
/
Analgesics, Non-Narcotic
/
Acetaminophen
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
BMJ Case Rep
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Reino Unido