Mendelian randomization analyses reveal causal relationship between liver volume and stroke.
J Stroke Cerebrovasc Dis
; 33(8): 107752, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38701939
ABSTRACT
BACKGROUND:
Observational studies have suggested a potential association between abdominal viscera volume and increased risk of stroke. However, the causal relationship remains unclear. This study aims to utilize Mendelian randomization (MR) to explore the genetic causal relationship between them.METHODS:
We conducted MR analysis to study the causal effects of five abdominal viscera volumes on stroke. The genetic variations of abdominal viscera volume were obtained from the UK Biobank, and the summary data for stroke and ischemic stroke were acquired from the MEGASTROKE consortium. This study employed inverse variance weighting (IVW), MR Egger, and weighted median methods. IVW served as the primary MR analysis method, supplemented by other sensitivity analyses to validate the robustness of the results.RESULTS:
We found that liver volume can causally increase the risk of stroke [odds ratio (OR) 1.13, 95 % confidence interval (CI) 1.03-1.25, P = 0.013] and ischemic stroke (OR 1.14, 95 % CI 1.03-1.26, P = 0.012). No causal relationships between other abdominal viscera volumes and stroke and ischemic stroke appeared to be present (P > 0.05). Sensitivity analyses confirmed the robustness of the results.CONCLUSION:
Our research findings indicate a causal relationship between liver volume and stroke, highlighting the potential role of liver volume in the onset of stroke. However, further basic and clinical research is needed to delve into the specific mechanisms underlying the relationship between liver volume and stroke, and to implement interventions aimed at reducing the impact of liver volume on stroke risk.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Predisposition to Disease
/
Mendelian Randomization Analysis
/
Ischemic Stroke
/
Liver
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Stroke Cerebrovasc Dis
Journal subject:
ANGIOLOGIA
/
CEREBRO
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Estados Unidos