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Topiramate treatment during adolescence induces short and long-term alterations in the reproductive system of female rats.
Bilibio, Júlia Oliveira; Forcato, Simone; da Silva, Deborah Gomes; Borges, Lorena Ireno; Frigoli, Giovanna Fachetti; Franco, Maria do Carmo Pinho; Fernandes, Glaura Scantamburlo Alves; Ceravolo, Graziela Scalianti; Gerardin, Daniela Cristina Ceccatto.
Affiliation
  • Bilibio JO; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil. Electronic address: julia.o.bilibio@gmail.com.
  • Forcato S; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil.
  • da Silva DG; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil.
  • Borges LI; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil.
  • Frigoli GF; Department of Immunology, Parasitology and General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
  • Franco MDCP; Division of Nephrology, School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
  • Fernandes GSA; Department of General Biology, State University of Londrina, Londrina, Paraná, Brazil.
  • Ceravolo GS; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil.
  • Gerardin DCC; Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil.
Reprod Toxicol ; 126: 108601, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38705260
ABSTRACT
Topiramate (TPM) is an antiepileptic drug used for treating epilepsy in children, and migraine in teenagers. In this context, preclinical studies with adult female rats observed reproductive system abnormalities following treatment with TPM. Additionally, exposure to endocrine disruptors during developmental plasticity periods, such as childhood and adolescence, may influence characteristics in the adult individual. This study evaluated whether treatment with TPM during developmental periods influences the reproductive system of female rats either immediately or in adult life. Female Wistar rats were treated with TPM (41 mg/Kg/day) by oral gavage from postnatal day (PND) 16-28, or PND 28-50, which correspond to childhood and adolescence, respectively, and euthanized either 24 h after the final administration or during adulthood. Treatment with TPM during adolescence induced short-term increase in uterus and ovary weights and reduction in endometrial stroma thickness. Adult animals treated during adolescence displayed reduced primordial ovarian follicles' numbers, and increased primary and pre-antral ovarian follicles' numbers. Treatment during childhood induced no short or long-term differences. These results indicate TPM treatment during adolescence is capable of inducing short and long-term alterations on the reproductive system of female Wistar rats.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovary / Uterus / Rats, Wistar / Topiramate / Anticonvulsants Limits: Animals Language: En Journal: Reprod Toxicol Journal subject: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovary / Uterus / Rats, Wistar / Topiramate / Anticonvulsants Limits: Animals Language: En Journal: Reprod Toxicol Journal subject: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Year: 2024 Document type: Article