Dabrafenib-trametinib in BRAF V600-mutated non-small-cell lung cancer: a single center real world experience.
Future Oncol
; : 1-7, 2024 May 06.
Article
in En
| MEDLINE
| ID: mdl-38709118
ABSTRACT
Aim:
We retrospectively evaluated the effect of dabrafenib/trametinib combination in patients with BRAF-mutated non-small-cell lung cancer (NSCLC) treated in a single center from 2017 to 2022. Patients The response and safety data of 42 patients (27 treated in first-line and 15 as second/subsequent lines) were analyzed.Results:
The objective response was 73.8%, with no differences between patients undergoing first- or second-line. A longer, statistically significant median progression-free survival (PFS) was observed in patients receiving the combination in first-line vs those in the second/subsequent lines (19.9 months [95% CI 19.7-20] vs 13.1 months [95% CI 8.6-17.6], respectively; p = 0.012). The median overall survival (OS) was 29.9 months (95% CI 14.1-45.7) for patients treated with the combination in first-line and 22.4 months (95% CI 14.6-30.2) for those treated in subsequent lines. The combination was well tolerated.Conclusion:
We confirm the efficacy of dabrafenib/trametinib in BRAF-V600-mutated NSCLC.
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Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Future Oncol
Year:
2024
Document type:
Article
Affiliation country:
Italia