Novel Effective Medical Therapy for Acanthamoeba Keratitis.
Eye Contact Lens
; 50(6): 279-281, 2024 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-38709240
ABSTRACT
PURPOSE:
To report first clinical use of novel medical treatment for Acanthamoeba keratitis.METHODS:
Interventional observational case series. Two patients with Acanthamoeba keratitis were unsuccessfully treated with polihexanide (PHMB) 0.02% and propamidine 0.1% for 6 weeks, then all were shifted in a compassionate use of PHMB 0.08% with novel standardized protocol. The postinterventional follow-up of patients was at least 7 months.RESULTS:
PHMB 0.08% eyedrops in a novel standardized protocol improved infection resolution and led to complete healing of the lesion after 4 weeks in the two cases. Corneal opacities and neovascularization decreased slowly, best-corrected visual acuity slightly improved and progressively increased in the further 7 months, and no infection recurrence occurred.CONCLUSIONS:
This preliminary report of two cases shows promising response to polihexanide 0.08% lowering drastically the illness duration, with reduced chance of recurrence, and mostly improving patients' quality of life.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biguanides
/
Acanthamoeba Keratitis
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Eye Contact Lens
Journal subject:
OFTALMOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Italia
Country of publication:
Estados Unidos