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Micelle-based fluorogenic sensing of trypsin: a sensitive method in pancreatic disease diagnosis.
Song, Hyebin; Choi, Haemin; Kim, Young-Sun; Lee, Seoung Ho.
Affiliation
  • Song H; Department of Chemistry, Daegu University, Gyeongsan 38453, Republic of Korea. slee@daegu.ac.kr.
  • Choi H; Department of Chemistry, Daegu University, Gyeongsan 38453, Republic of Korea. slee@daegu.ac.kr.
  • Kim YS; Department of Horticultural Science, College of Natural and Life Sciences, Daegu University, Gyeongsan 38453, Republic of Korea.
  • Lee SH; Department of Chemistry, Daegu University, Gyeongsan 38453, Republic of Korea. slee@daegu.ac.kr.
Org Biomol Chem ; 22(21): 4243-4248, 2024 05 29.
Article in En | MEDLINE | ID: mdl-38712975
ABSTRACT
Protamine-mediated micellar aggregates, featuring an AIE-based fluorescent sensor, facilitate efficient detection of trypsin activity. This method enables the detection of trypsin at exceptionally low concentrations (0.01-0.1 µg mL-1) in urine, demonstrating its potential for early clinical diagnosis of trypsin-related pancreatic diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Diseases / Trypsin / Fluorescent Dyes / Micelles Limits: Humans Language: En Journal: Org Biomol Chem / Org. biomol. chem / Organic & biomolecular chemistry Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Diseases / Trypsin / Fluorescent Dyes / Micelles Limits: Humans Language: En Journal: Org Biomol Chem / Org. biomol. chem / Organic & biomolecular chemistry Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Country of publication: Reino Unido